The Future of Antifungal Agents. Non Azole Antifungal Agents.
نویسندگان
چکیده
منابع مشابه
Antifungal agents: Polyene, azole, antimetabolite, other and future agents
Antifungals have always been considered as one of the astonishing discoveries of the 20th century. This is correct, but the real marvel is the development of antifungal resistance in hospitals, communities, and the environment concomitant with their use. Fungal infections have emerged as an important clinical threat, with significant associated morbidity and mortality. This study is desig...
متن کاملCurrent and emerging azole antifungal agents.
Major developments in research into the azole class of antifungal agents during the 1990s have provided expanded options for the treatment of many opportunistic and endemic fungal infections. Fluconazole and itraconazole have proved to be safer than both amphotericin B and ketoconazole. Despite these advances, serious fungal infections remain difficult to treat, and resistance to the available ...
متن کاملRational design and synthesis of homochiral azole antifungal agents*
The first synthesis of both enantiomers of the antifungal drug bifonazole (1a) and related imidazole compounds 1i and 5b,c is described, starting from enantiomerically pure or enriched amines 6a–d. Construction of the imidazole ring on amines 6a–d was performed in a straightforward manner affording the final compounds in good overall yield and with very high enantiomeric purity, as determined b...
متن کاملAntifungal Agents
Continued advancement of medical science offers life-saving treatment options for a variety of hematologic, oncologic, and rheumatologic conditions. Immunosuppression, a common therapeutic side-effect, predisposes patients to invasive fungal infections, which are escalating in prevalence. The development of effective, welltolerated antifungals has lagged behind the advances of antibacterial the...
متن کاملLipid-based antifungal agents.
The spectrum of human mycoses ranges from superficial and local to disseminated and life-threatening infections. Opportunistic fungal infections of the immunocompromised host are difficult to treat and result in significant mortality. Antifungal drugs with a broad spectrum of activity along with acceptable efficacy and an optimal safety profile are an option for the treatment of these infection...
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ژورنال
عنوان ژورنال: Nippon Ishinkin Gakkai Zasshi
سال: 1999
ISSN: 0916-4804,1882-0476
DOI: 10.3314/jjmm.40.157